Human persistent atrial fibrillation is maintained by rotors: the jury is still out.
نویسندگان
چکیده
Human Persistent Atrial Fibrillation Is Maintained by Rotors: The Jury Is Still Out Tomos E. Walters, MBBS; Jonathan M. Kalman, MBBS, PhD · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · 517 123I-Meta-Iodobenzylguanidine Guanidine–Guided Ventricular Tachycardia Ablation: Will Expanding the Target Improve the Aim? Niti R. Aggarwal, MD; Panithaya Chareonthaitawee, MD · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · 520
منابع مشابه
Maintenance of Atrial Fibrillation
Presented in the following review are the insights on atrial fibrillation (AF) gained from our recent simultaneous endo-epicardial transmural and panoramic optical mapping studies of the human atria that may begin to resolve the controversy about AF maintenance mechanisms. It is still hotly debated whether the sustaining mechanism of AF involves multiwavelets self-replicating across the entire ...
متن کاملTheoretical considerations for mapping activation in human cardiac fibrillation.
Defining mechanisms for cardiac fibrillation is challenging because, in contrast to other arrhythmias, fibrillation exhibits complex non-repeatability in spatiotemporal activation but paradoxically exhibits conserved spatial gradients in rate, dominant frequency, and electrical propagation. Unlike animal models, in which fibrillation can be mapped at high spatial and temporal resolution using o...
متن کاملClinical mapping approach to diagnose electrical rotors and focal impulse sources for human atrial fibrillation.
INTRODUCTION The perpetuating mechanisms for human atrial fibrillation (AF) remain undefined. Localized rotors and focal beat sources may sustain AF in elegant animal models, but there has been no direct evidence for localized sources in human AF using traditional methods. We developed a clinical computational mapping approach, guided by human atrial tissue physiology, to reveal sources of huma...
متن کاملHuman Ventricular Fibrillation
Amajor controversy in cardiac electrophysiology is whether ventricular fibrillation (VF) is maintained by wandering wavelets or mother rotors. On the basis of a computer model of atrial fibrillation by Moe1 developed in 1962, fibrillation was hypothesized to be maintained by multiple small, wandering wavelets, in which the activation pattern is constantly changing. According to the wandering wa...
متن کاملFocal Impulse and Rotor Modulation for Paroxysmal Atrial Fibrillation
Therapy for atrial fibrillation (AF) remains suboptimal, largely because of uncertainty in its mechanisms. While the ‘‘triggers’’ versus ‘‘substrate’’ debate continues to rage, it is not clear that this is central. All supraand ventricular arrhythmias are initiated from sinus rhythm by ‘‘triggers,’’ and successful therapy targets their sustaining mechanisms rather than triggers. Paroxysmal AF, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Circulation. Arrhythmia and electrophysiology
دوره 8 3 شماره
صفحات -
تاریخ انتشار 2015